In vivo (Athens, Greece) · 2020
Drug Delivery Properties of Nanocomposite Particles for Inhalation: Comparison of Drug Concentrations in Lungs and Blood.
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Takeuchi Issei, Koshi Yuki, Makino Kimiko
Аннотация
BACKGROUND/AIM: Nanocomposite particles are suitable for inhalation; however, their systemic migration has not been confirmed. The aim of this study was to compare drug concentrations in lungs and blood after inhalation of nanocomposite particles.
MATERIALS AND METHODS: Rifampicin (RFP) was used as a model drug. Nanocomposite particles were prepared from dichloromethane with RFP and poly(DL-lactic acid-co-glycolic acid) (PLGA) dissolved in an amino acid aqueous solution using a spray dryer. Measurement of RFP concentrations in lung and blood of mice was performed by in vivo tests.
RESULTS: Compared with the oral administration group as a control, the RFP concentration in the lungs was significantly higher in the inhalation group. In addition, studies with a fluorescent substance suggested sustained release of drugs from nanocomposite particles in the lungs.
CONCLUSION: Nanocomposite particles deliver pulmonary drug in an efficient and sustained manner.
MATERIALS AND METHODS: Rifampicin (RFP) was used as a model drug. Nanocomposite particles were prepared from dichloromethane with RFP and poly(DL-lactic acid-co-glycolic acid) (PLGA) dissolved in an amino acid aqueous solution using a spray dryer. Measurement of RFP concentrations in lung and blood of mice was performed by in vivo tests.
RESULTS: Compared with the oral administration group as a control, the RFP concentration in the lungs was significantly higher in the inhalation group. In addition, studies with a fluorescent substance suggested sustained release of drugs from nanocomposite particles in the lungs.
CONCLUSION: Nanocomposite particles deliver pulmonary drug in an efficient and sustained manner.