Journal of the Association of Genetic Technologists · 2020
Genetic Variants in Host Protein Disulfide Isomerase 2 (PDIA2) are Associated with Susceptibility to Chlamydia Trachomatis Infection.
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Zysk Christopher, Williams Steven, Chavarria Itzel, Wilson Hailey, Balogun Adedayo, Jacobs Emily, Kaminski Rachel, Foma Baru-Ta, Johnson Jack, Lux Wesley, McCoy Kristyn, Morales Stephen, Sanchez Gina, Grubb Paul, Littlejohn Melanie, Mize Ryan, Moreno Jorge, Pirtle Caryn, Hendrix Ericka C, Bennett Katie M
Аннотация
Objective: Host genetics can influence susceptibility to Chlamydia trachomatis infection. This study examined two genetic variants in human protein disulfide isomerase A2 (PDIA2), a member of a family of protein chaperones that participate in the chlamydial life cycle. Methods: A total of 278 male and female subjects, positive or negative for C. trachomatis infection, were genotyped for PDIA2 polymorphisms (rs400037 and rs419949) using real-time PCR and pyrosequencing. Results: There was a significant odds ratio of 8.21 (95% CI: 1.77-38.16) for rs400037 and 9.89 (95% CI: 1.19-82.10) for rs419949, for the AA genotypes. Conclusion: This indicates that individuals with the PDIA2 AA genotypes have significantly increased susceptibility to C. trachomatis infection as compared to the other PDIA2 genotypes (GG, GA). This correlation may be explained by an interactive role of host protein disulfide isomerases in the attachment and entry of C. trachomatis into cells.