[Clinical effects of recombinant versus urinary gonadotropins in ovulation induction].

OBJECTIVE

To present an overview of trials and discussion focused on the clinical characteristics of recombinant gonadotropins compared with urinary ones in ovulation induction.

SUBJECT: Review article.

SETTING

Sanatorium Pronatal, Prague.

SUBJECT AND METHOD: The subject of the study is to compare the clinical characteristics of recombinant gonadotropins versus urinary ones focused on the daily dose of FSH achieving FSH threshold and the risk of multifollicular development in ovulation induction before intrauterine insemination, number of follicles and oocytes, the risk of ovarian hyperstimulation syndrome (OHSS), total consumption of FSH, cost effectiveness and expected pregnancy rate during in vitro fertilization technique. The method is a MEDLINE research of articles from 1994 to 2010.

CONCLUSIONS

Data demonstrates that recombinant FSH (rFSH) offers higher ovarian response, less consumption of gonadotropins, lower risk of complications (multiple pregnancy and OHSS) compared with urinary FSH (uFSH). Expected pregnancy rate is probably comparable.