A large-sample study of sex differences in functional cerebral lateralization.

For practitioners, the importance of sex differences in lateralization lies in their potential prediction of susceptibility to and recovery from hemispheric damage. However, previous literature reviews suggest that sex accounts for only 0.1-1% of the variance in asymmetry scores. Here a large-sample, single-laboratory approach uses tasks requiring the recognition of bargraphs, dichotic words, facial emotions, locations, and visual words, and visual line bisection, each sensitive to lateralization of a separate mental module. The results agree with previous reviews, with sex accounting for a maximum of 0.9% and an average of 0.09% of the variance, suggesting that sex has little predictive clinical utility. However, the strength of relationship between sex and laterality depends on the nature of the lateralized task, presumably because of differences between tasks in underlying lateralized modules.