American journal of translational research · 2026
Combined therapy with vitamin D, mesalazine, and microecological preparations improves clinical outcome in ulcerative colitis.
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Xu Jiancheng, Wu Kundong, Wang Na, Wang Junjie, Wang Zhendong, Li Lingling, Gao Jihua, Guo Jiaojiao
Аннотация
OBJECTIVE: To evaluate the clinical efficacy of adjunctive vitamin D to mesalazine combined with microecological preparations in the treatment of ulcerative colitis.
METHODS: A retrospective analysis was conducted on the clinical data of 103 patients with ulcerative colitis. The conventional treatment group (n=54) received mesalazine plus microecological preparations, while the combined treatment group (n=49) received additional vitamin D. Both groups were treated for one month. The efficacy, safety, and mechanistic indicators were compared between the two groups.
RESULTS: After one month of treatment, the combined treatment group showed better results than the conventional treatment group in terms of endoscopic findings, disease activity, inflammatory indicators, intestinal barrier function, oxidative stress levels, and the Inflammatory Bowel Disease Questionnaire (all P<0.05). No significant difference was found in the incidence of adverse reactions (P>0.05).
CONCLUSION: Vitamin D supplementation on the basis of mesalazine combined with microecological preparations can improve the clinical efficacy, mucosal healing, and related biological indicators in patients with ulcerative colitis, and has good safety.
METHODS: A retrospective analysis was conducted on the clinical data of 103 patients with ulcerative colitis. The conventional treatment group (n=54) received mesalazine plus microecological preparations, while the combined treatment group (n=49) received additional vitamin D. Both groups were treated for one month. The efficacy, safety, and mechanistic indicators were compared between the two groups.
RESULTS: After one month of treatment, the combined treatment group showed better results than the conventional treatment group in terms of endoscopic findings, disease activity, inflammatory indicators, intestinal barrier function, oxidative stress levels, and the Inflammatory Bowel Disease Questionnaire (all P<0.05). No significant difference was found in the incidence of adverse reactions (P>0.05).
CONCLUSION: Vitamin D supplementation on the basis of mesalazine combined with microecological preparations can improve the clinical efficacy, mucosal healing, and related biological indicators in patients with ulcerative colitis, and has good safety.