Reproductive toxicology (Elmsford, N.Y.) · 2019
Maternal and fetal outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKAGFP.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Boareto Ana Cláudia, Gomes Caroline, Centeno Müller Juliane, da Silva Jonas Golart, Vergara Fernanda, Salum Noruê, Maristany Sargaço Rafaela, de Carvalho Rosângela Ribeiro, Queiroz Telles José Ederaldo, Marinho Cláudio Romero Farias, Paumgartten Francisco José Roma, Dalsenter Paulo Roberto
Аннотация
Malaria in pregnant women is associated with risk of maternal and perinatal morbidity and mortality, and there are few antimalarial drugs considered safe to treat them, so it is necessary to develop safer antimalarial medicines. The goal of this study was to develop an animal model for human malaria during pregnancy by characterizing the maternal and fetal outcomes in malaria infected Swiss mice. For that, in the present study, we evaluated the outcome of pregnancy in Swiss mice infected with Plasmodium berghei ANKAGFP. We observed a reduction of fetal body weight and signs of skeletal ossification retardation in the offspring of mice infected on GD 12. The group of mice infected with malaria presented premature deliveries and histopathology changes consistent with placental malaria. Our study suggests that Swiss Webster mice infected with P. berghei ANKAGFP on GD 12 might be a valuable model to investigate the safety and the efficacy of new antimalarial drugs indicated to pregnant women.