Evaluation of Organically Versus Synthetically Derived Multivitamin and Mineral Supplementation on Circulatory Concentration in Healthy Humans: A Single-Blinded Randomized Intervention Study.

BACKGROUND

Growing consumer interest in organic products has stimulated demand for organically sourced multivitamins and minerals (MVM); however, evidence comparing their efficacy with conventional synthetic formulations is limited.

OBJECTIVES

This study aims to assess circulatory concentrations of organically sourced (ORG) compared with synthetically produced (SYN) MVM supplements.

METHODS

Single-blind randomized 30-d intervention, in which healthy adults (n = 62) ingested either ORG or SYN-sourced MVM formulations. Circulating MVM concentrations were assessed at baseline and postintervention. A subset of participants (n = 19) completed an acute crossover trial for assessment 2 h postingestion.

RESULTS

Both ORG and SYN produced comparable changes in circulating micronutrient concentrations across 2-h and 30-d ingestion protocols, with no significant changes between groups for all vitamins and minerals. Over 30-d ingestion resulted in significant within-group changes; elevated biotin concentrations over time (F = 5.36, P = 0.022), and B9 folate (F = 5.46, P = 0.021), in both the ORG (P < 0.05) and SYN groups (P < 0.05). No changes were observed for vitamin B12, vitamin C, vitamin D, calcium, zinc, iron, ferritin, and transferrin concentrations. Two-hour ingestion resulted in significant increases in vitamin B12, vitamin D, calcium, zinc, iron, and ferritin for both supplement types; however, elevated folate and transferrin were present in ORG only (both P < 0.01).

CONCLUSION

Organic and synthetic MVM formulations demonstrated similar postingestion circulatory profiles. These findings support the use of organic MVMs as functionally comparable alternatives to SYN supplements, aligning with increasing consumer demand for organic, naturally derived health products.