Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2005
Lipid-based Nose Ointment for Allergic Rhinitis.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Geisthoff Urban Wilhelm, Blum Andreas, Rupp-Classen Marianne, Plinkert Peter-Karl
Аннотация
OBJECTIVE: To assess the efficacy of a lipid-based nose ointment in treating allergic rhinitis.
STUDY DESIGN AND SETTING: Prospective, open, randomized, controlled clinical study in the outpatient departments of 2 tertiary care centers.
RESULTS: No specific adverse effects were observed. The nose ointment under investigation led to a significant improvement in sneezing and nasal itching (17 patients). There was no significant change for nasal congestion and rhinorrhea in the intention-to-treat sets. However, there was still a significant drop of the mean relative total symptom score derived from the individual scores. All scores remained unchanged in the untreated control group (16 patients).
CONCLUSION: Topical application of the nose ointment as a supportive treatment leads to a significant improvement of symptoms in allergic rhinitis.
SIGNIFICANCE: The prevalence of allergic rhinitis is about 10% to 20% in the population. Our study results are encouraging and should be assessed in further research because changes in the therapeutic guidelines may be suggested.
EBM RATING: A.
STUDY DESIGN AND SETTING: Prospective, open, randomized, controlled clinical study in the outpatient departments of 2 tertiary care centers.
RESULTS: No specific adverse effects were observed. The nose ointment under investigation led to a significant improvement in sneezing and nasal itching (17 patients). There was no significant change for nasal congestion and rhinorrhea in the intention-to-treat sets. However, there was still a significant drop of the mean relative total symptom score derived from the individual scores. All scores remained unchanged in the untreated control group (16 patients).
CONCLUSION: Topical application of the nose ointment as a supportive treatment leads to a significant improvement of symptoms in allergic rhinitis.
SIGNIFICANCE: The prevalence of allergic rhinitis is about 10% to 20% in the population. Our study results are encouraging and should be assessed in further research because changes in the therapeutic guidelines may be suggested.
EBM RATING: A.
Предметные рубрики MeSH
Administration, IntranasalAdultAmbulatory CareAnti-Allergic AgentsDose-Response Relationship, DrugDrug Administration ScheduleDrug CarriersDrug Therapy, CombinationFemaleFollow-Up StudiesHumansLipidsMaleOintmentsProspective StudiesReference ValuesRhinitis, Allergic, PerennialSeverity of Illness IndexSingle-Blind MethodStatistics, NonparametricTreatment Outcome