Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Global Cardiovascular Risk Consortium, Magnussen Christina, Ojeda Francisco M, Leong Darryl P, Alegre-Diaz Jesus, Amouyel Philippe, Aviles-Santa Larissa, De Bacquer Dirk, Ballantyne Christie M, Bernabé-Ortiz Antonio, Bobak Martin, Brenner Hermann, Carrillo-Larco Rodrigo M, de Lemos James, Dobson Annette, Dörr Marcus, Donfrancesco Chiara, Drygas Wojciech, Dullaart Robin P, Engström Gunnar, Ferrario Marco M, Ferrières Jean, de Gaetano Giovanni, Goldbourt Uri, Gonzalez Clicerio, Grassi Guido, Hodge Allison M, Hveem Kristian, Iacoviello Licia, Ikram M Kamran, Irazola Vilma, Jobe Modou, Jousilahti Pekka, Kaleebu Pontiano, Kavousi Maryam, Kee Frank, Khalili Davood, Koenig Wolfgang, Kontsevaya Anna, Kuulasmaa Kari, Lackner Karl J, Leistner David M, Lind Lars, Linneberg Allan, Lorenz Thiess, Lyngbakken Magnus Nakrem, Malekzadeh Reza, Malyutina Sofia, Mathiesen Ellisiv B, Melander Olle, Metspalu Andres, Miranda J Jaime, Moitry Marie, Mugisha Joseph, Nalini Mahdi, Nambi Vijay, Ninomiya Toshiharu, Oppermann Karen, d'Orsi Eleonora, Pająk Andrzej, Palmieri Luigi, Panagiotakos Demosthenes, Perianayagam Arokiasamy, Peters Annette, Poustchi Hossein, Prentice Andrew M, Prescott Eva, Risérus Ulf, Salomaa Veikko, Sans Susana, Sakata Satoko, Schöttker Ben, Schutte Aletta E, Sepanlou Sadaf G, Sharma Sanjib Kumar, Shaw Jonathan E, Simons Leon A, Söderberg Stefan, Tamosiunas Abdonas, Thorand Barbara, Tunstall-Pedoe Hugh, Twerenbold Raphael, Vanuzzo Diego, Veronesi Giovanni, Waibel Julia, Wannamethee S Goya, Watanabe Masafumi, Wild Philipp S, Yao Yao, Zeng Yi, Ziegler Andreas, Blankenberg Stefan
Аннотация
METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.
RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).
CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).