Clinical transplantation · 2013
Neopterin is associated with cardiovascular events and all-cause mortality in renal transplant patients.
СтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Pihlstrøm Hege, Mjøen Geir, März Winfried, Olav Dahle Dag, Abedini Sadollah, Holme Ingar, Fellström Bengt, Jardine Alan, Pilz Stefan, Holdaaas Hallvard
Аннотация
BACKGROUND: Inflammatory markers show significant associations with cardiovascular events and all-cause mortality after kidney transplantation. Neopterin, reflecting interferon-γ-release, may better reflect the proinflammatory state of recipients than less specific markers.
METHODS: Kidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality.
RESULTS: After adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p = 0.009) and all-cause mortality (p = 0.002). Endpoints were more frequent with increasing quartiles of neopterin-to-creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first.
CONCLUSIONS: This long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes.
METHODS: Kidney transplant recipients in the Assessment of LEscol in Renal Transplant (ALERT) trial were examined and investigated for an association between serum neopterin and subsequent clinical events: graft loss, major cardiovascular events (MACE) and all-cause mortality.
RESULTS: After adjustment for established and emerging risk factors neopterin expressed as neopterin-to-creatinine ratio was significantly associated with MACE (p = 0.009) and all-cause mortality (p = 0.002). Endpoints were more frequent with increasing quartiles of neopterin-to-creatinine ratio. The incidence rates of MACE and all-cause mortality were significantly increased in the upper quartiles compared with the first.
CONCLUSIONS: This long-term prospective analysis in stable kidney allograft recipients suggests that neopterin is associated with long-term risk of cardiovascular events and all-cause mortality, but not renal outcomes.
Предметные рубрики MeSH
AdultAgedBiomarkersCardiovascular DiseasesCause of DeathCreatinineDouble-Blind MethodFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionHumansKidney Failure, ChronicKidney Function TestsKidney TransplantationMaleMiddle AgedNeopterinPostoperative ComplicationsPrognosisProspective StudiesRisk FactorsSurvival Rate