Visualization of the Gallbladder on 177 Lu-FAP-2286 SPECT/CT Imaging : A Potential Pitfall.

Fibroblast activation protein (FAP) is a membrane-bound protease predominantly expressed on the surface of cancer-associated fibroblasts activated within the solid tumor microenvironment, while its expression remains minimal in normal tissues. Following radiolabeling, FAP-2286 has demonstrated favorable diagnostic performance and promising therapeutic potential in cancer. The image illustrates the accumulation of 177 Lu-FAP-2286 in the gallbladder, but correlative imaging and knowledge of the radiopharmaceutical helped to avoid a diagnostic pitfall.