Presse medicale (Paris, France : 1983) · 1998
[Adenocarcinoma of the pancreas. General characteristics].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
André T, Balosso J, Louvet C, Gligorov J, Callard P, de Gramont A, Izrael V
Аннотация
EPIDEMIOLOGY: Pancreatic carcinoma ranks fifth among the leading causes of cancer death in developed countries. Although the incidence of pancreatic cancer is about 10 per 100,000 inhabitants, the five-year overall survival is barely one to 4%. Few risk factors have been identified. Smoking increases the relative risk by 1.5, chronic pancreatitis by 26. Hereditary formes are rare.
PATHOLOGY AND MOLECULAR ABNORMALITIES: Adenocarcinomas of the ductal phenotype represents about 90% of the pancreatic tumors. Seventy percent of adenocarcinomas are located in the head. Mutations of K-ras oncogene and p53 anti-oncogene are noted, respectively, in 80 to 90% and 70% of the ductal adenocarcinomas. The mutation of p53 is associated with a poor prognosis. Certain less frequent forms such as mucinous cystadenocarcinomas, or intraductal papillary-mucinous tumors seem to have a better prognosis. However, this is not true for acinar cell carcinomas responsible for various paraneoplastic syndromes.
PATTERN OF SPREAD: The disease arises in the ductal epithelium and rapidly spreads to regional lymph nodes and the liver. At diagnosis, nodal involvement is found in 80% of cases. Half of the patients have detectable visceral metastasis with a median survival of three to six months. Among the remaining non metastatic patients, approximately one in 5 has undetected peritonal carcinomatosis. Only 10 to 20% of the patients undergo surgical complete resection with a median survival of 15 to 19 months.
PATHOLOGY AND MOLECULAR ABNORMALITIES: Adenocarcinomas of the ductal phenotype represents about 90% of the pancreatic tumors. Seventy percent of adenocarcinomas are located in the head. Mutations of K-ras oncogene and p53 anti-oncogene are noted, respectively, in 80 to 90% and 70% of the ductal adenocarcinomas. The mutation of p53 is associated with a poor prognosis. Certain less frequent forms such as mucinous cystadenocarcinomas, or intraductal papillary-mucinous tumors seem to have a better prognosis. However, this is not true for acinar cell carcinomas responsible for various paraneoplastic syndromes.
PATTERN OF SPREAD: The disease arises in the ductal epithelium and rapidly spreads to regional lymph nodes and the liver. At diagnosis, nodal involvement is found in 80% of cases. Half of the patients have detectable visceral metastasis with a median survival of three to six months. Among the remaining non metastatic patients, approximately one in 5 has undetected peritonal carcinomatosis. Only 10 to 20% of the patients undergo surgical complete resection with a median survival of 15 to 19 months.