Revista da Sociedade Brasileira de Medicina Tropical · 2020
In vivo antileishmanial activity of Annona mucosa extracts.
СтатьяНазвание и аннотация: Перевод в очереди
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Lima Janaína Paolucci Sales de, Pinheiro Maria Lúcia Belém, Allaman Ivan Bezerra, Silva-Jardim Izaltina
Аннотация
INTRODUCTION: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem.
METHODS: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa.
RESULTS: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels.
CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.
METHODS: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa.
RESULTS: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels.
CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.