Медицинская библиотека · Vascular health and risk management · 2020

Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients.

Sawai Yusuke, Yamanaka Yuta, Nomura Shosaku

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Аннотация

BACKGROUND

The aim was to evaluate factor XIII activity (FXIIIa) and monocyte-derived microparticles (MDMPs) in cancer patients.

METHODS

In total, 138 cancer patients (31 malignant lymphomas, 39 multiple myelomas, and 68 lung cancers) were analyzed. We measured various biomarkers including FXIIIa and MDMPs.

RESULTS

The values of endothelial activation markers, monocyte chemoattractant peptide (MCP)-1, soluble (s)CD14, and MDMPs were higher in cancer patients than in non-cancerous controls. MCP-1, sCD14, and MDMPs were significantly correlated with FXIIIa in multivariate analysis in cancer patients. In addition, MCP-1, sCD14, and MDMP levels were significantly increased in the high FXIIIa group of patients. Finally, the survival rate of the high FXIIIa group was significantly poor in the Kaplan-Meier analysis.

CONCLUSION

These results suggest that abnormal levels of FXIIIa and MDMPs may offer promise as poor prognostic factors in cancer patients.

Для цитирования: Sawai Yusuke, Yamanaka Yuta, Nomura Shosaku. Clinical Significance of Factor XIII Activity and Monocyte-Derived Microparticles in Cancer Patients.. Vascular health and risk management. 2020. DOI: 10.2147/vhrm.s240500.

Предметные рубрики MeSH

Adult Aged Biomarkers Case-Control Studies Cell-Derived Microparticles Factor XIII Female Humans Male Middle Aged Monocytes Neoplasms Thrombosis

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