Biochemical and biophysical research communications · 2026
Hydrogels in Pharmaceutical Formulation: Properties, formulation strategies, and drug delivery applications.
СтатьяОбзорНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Kannan Suriya Prakaash, Parameswaran Dakshinesh, Narayanasamy Damodharan
Аннотация
OBJECTIVES: This review aims to provide a systematic overview of hydrogel systems as pharmaceutical excipients for drug delivery. It focuses on their classification, formulation strategies, physicochemical properties, and applicability across different routes of administration.
SIGNIFICANCE: Hydrogels have progressed into multifunctional excipients capable of modulating drug release, enhancing residence time, and improving patient compliance. This review consolidates formulation-oriented knowledge while addressing translational, manufacturing, and regulatory considerations.
KEY FINDINGS: Hydrogels are classified based on source, polymer type, network charge, physical form, and cross-linking methods. Key excipient properties-including swelling, porosity, mechanical strength, biodegradability, and environmental responsiveness-govern performance. Diverse fabrication techniques support tailored design for oral, topical, transdermal, ocular, rectal, and injectable delivery. Challenges such as scalability and reproducibility persist, while stimuli-responsive and composite hydrogels offer promising solutions.
CONCLUSION: This review highlights a formulation-driven framework for the rational design and clinical translation of hydrogel-based pharmaceutical excipients in advanced drug delivery systems.
SIGNIFICANCE: Hydrogels have progressed into multifunctional excipients capable of modulating drug release, enhancing residence time, and improving patient compliance. This review consolidates formulation-oriented knowledge while addressing translational, manufacturing, and regulatory considerations.
KEY FINDINGS: Hydrogels are classified based on source, polymer type, network charge, physical form, and cross-linking methods. Key excipient properties-including swelling, porosity, mechanical strength, biodegradability, and environmental responsiveness-govern performance. Diverse fabrication techniques support tailored design for oral, topical, transdermal, ocular, rectal, and injectable delivery. Challenges such as scalability and reproducibility persist, while stimuli-responsive and composite hydrogels offer promising solutions.
CONCLUSION: This review highlights a formulation-driven framework for the rational design and clinical translation of hydrogel-based pharmaceutical excipients in advanced drug delivery systems.