Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013
Urinary neutrophil gelatinase-associated lipocalin predicts graft loss after acute kidney injury in kidney transplant.
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Ramírez-Sandoval Juan C, Barrera-Chimal Jonatan, Simancas Perla E, Rojas-Montaño Alejandro, Correa-Rotter Ricardo, Bobadilla Norma A, Morales-Buenrostro Luis E
Аннотация
OBJECTIVE: Establish the prognostic value for graft loss of urinary neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), interleukin-18 (uIL-18), and heat shock protein 72 (uHsp72) in kidney transplant recipients (KTR) with acute kidney injury (AKI).
METHODS: Biomarkers were measured in 67 KTR with AKI caused by different entities.
RESULTS: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.
METHODS: Biomarkers were measured in 67 KTR with AKI caused by different entities.
RESULTS: After 1 year, 11 KTR with graft loss had higher uNGAL compared to KTR without loss (p < 0.001). There were no differences for uKIM-1, uIL-18 and uHsp-72. uNGAL >200 ng/mL had 84% sensitivity and 86% specificity for graft loss (ROC AUC: 0.89, 95% CI: 0.81-0.97). uNGAL may be useful to predict graft loss after AKI.