Early-onset colorectal cancer in Argentina: a multicenter surgical analysis of incidence, stage, and metastatic patterns.
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Campana Juan Pablo, Cifone Tomas, Salazar Esteban Gonzalez, Rossi Gustavo, Mentz Ricardo, Vaccaro Carlos, Daneri Ma Dolores, Patron Uriburu Juan Carlos, Cillo Mariano, Ruiz Hernan, Estefania Diego, Rotholtz Nicolas, Harriott Camila Bras, Bun Maximiliano, Campagno Fiorella, Carrie Augusto, Santillan Mateo, Avellaneda Nicolás, Chwat Carina, Alexandre Flavia, Rosato Guillermo, Valli Diego, Duarte Mauro Ramirez, Alesandrini Agustín, Perriello Juan, Miranda Nadia, Leiro Fabio, Bigerna Martina, Bianchi Romina, Gondolesi Gabriel, Gonzalez Marcos, Moreno Lisandro, Bozzetti Magdalena, Lucas Macarena, Sotelo Juan Manuel, Leone Ana Ines, Jacinto Pamela, Canelas Alejandro, Farina Pablo, Lumi Carlos Miguel, Collia Avila Karina, Caruso Emiliano, Muñoz Juan Pablo, Mira Gesto Natalia, Marasca Milagros, Espino Julieta, Trama Mauro, Cedermas Mariela, Arbios Pablo, Zanoni Gerardo, Minoldo Javier, Vallejos Pereira Guillermo, Giordanino Juan Manuel, Salinas Sosa Luz Maria, Pierotti Agustin, Gorreta Flavia, Danielli Ezequiel, Rodriguez Gerardo Martín, Canesin Camilo Sebastian, Bertani Diego, Minati Walther, Carrozzo Eduardo, Molina Rodrigo, Robales Carlos, Francisco Adrian, Hendl Maria Paula, Marcucci Gustavo, Lorenzi Lisandro, Marchetti Nestor, Gigli Juan, Posner Federico, Schor Marcelo, Balmaceda Ruben, Galvarini Martin, Agnella Yanina, Barranco María Manuela, Paredes Franco, Velásquez Sabrina, Girardini Javier, Sesma Juliana, Argentinian Colorectal Cancer Consortium
Аннотация
METHODS: In this retrospective, multicenter cohort study, we analyzed adult patients who underwent colorectal cancer surgery between April 2022 and December 2023. The registry included 1829 patients, of whom 961 were male (52.5%) and 868 were female (47.5%). Mean age was 41.6 years (range 18-49) in the EOCRC group and 68.8 years (range 50-98) in the late-onset colorectal cancer (LOCRC) group. Descriptive statistics were used to summarize patient and tumor characteristics. Comparisons between EOCRC (<50 years) and LOCRC (≥50 years) were performed using χ2 tests. Ethnicity data were not available.
FINDINGS: EOCRC accounted for 15.4% of surgically treated cases, with over two-thirds occurring among individuals aged 40-49 years. Compared with LOCRC, EOCRC patients more frequently presented with advanced tumor stages (T3-T4), higher lymph node positivity, and a greater prevalence of metastases. Tumor location differed between groups, with EOCRC predominating in the rectum and LOCRC showing a right-sided predominance.
INTERPRETATION: This national multicenter surgical registry analysis reveals substantial differences in stage and metastatic burden between younger and older colorectal cancer patients in Argentina. The high prevalence of advanced disease among individuals aged 40-49 years supports consideration of earlier initiation of colorectal cancer screening.
FUNDING: The Universidad Abierta Interamericana provided partial funding for the publication of this work.