ZnCl2-catalysed transfer hydrogenation of carbonyls and chemoselective reduction of the CC bond in α,β-unsaturated ketones.

This manuscript describes chemoselective reduction of CC in α,β-unsaturated ketones and the transfer hydrogenation of aldehydes and ketones catalysed by ZnCl2-phosphinamino-triazolyl-pyridine (0.5 mol%) using KOH/iPrOH as a H2 source. A detailed mechanistic study using DFT calculations (B3LYP-D3/def2-TZVP) revealed the key role of metal-ligand cooperation (MLC) in the catalytic reaction demonstrating the non-innocent behaviour of the phosphine ligand.