Nature communications · 2023
An interactive murine single-cell atlas of the lung responses to radiation injury.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Ошибки и ограничения
История · было → стало
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Curras-Alonso Sandra, Soulier Juliette, Defard Thomas, Weber Christian, Heinrich Sophie, Laporte Hugo, Leboucher Sophie, Lameiras Sonia, Dutreix Marie, Favaudon Vincent, Massip Florian, Walter Thomas, Mueller Florian, Londoño-Vallejo José-Arturo, Fouillade Charles
Аннотация
Radiation Induced Lung Injury (RILI) is one of the main limiting factors of thorax irradiation, which can induce acute pneumonitis as well as pulmonary fibrosis, the latter being a life-threatening condition. The order of cellular and molecular events in the progression towards fibrosis is key to the physiopathogenesis of the disease, yet their coordination in space and time remains largely unexplored. Here, we present an interactive murine single cell atlas of the lung response to irradiation, generated from C57BL6/J female mice. This tool opens the door for exploration of the spatio-temporal dynamics of the mechanisms that lead to radiation-induced pulmonary fibrosis. It depicts with unprecedented detail cell type-specific radiation-induced responses associated with either lung regeneration or the failure thereof. A better understanding of the mechanisms leading to lung fibrosis will help finding new therapeutic options that could improve patients' quality of life.