European neurology · 2009
Wernicke's encephalopathy with cortical abnormalities: clinicoradiological features: report of 3 new cases and review of the literature.
Клинический случайСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Sakurai Keita, Sasaki Shigeru, Hara Masaki, Yamawaki Takemori, Shibamoto Yuta
Аннотация
OBJECTIVE: To investigate clinical and magnetic resonance imaging (MRI) features of Wernicke's encephalopathy with cortical abnormalities (WEc).
METHODS: We retrospectively evaluated the clinical features and MRI findings in 3 cases of WEc in comparison with those of 7 previously reported cases.
RESULTS: Besides the classical triad of ocular abnormalities, ataxia and global confusion, muscular weakness of all extremities was frequently recognized (5 of 6 evaluable cases; 83%). During the clinical courses, 2 patients (20%) died and 1 fell into a vegetative state. The cortical abnormalities were distributed in the frontal and parietal lobes, especially around the bilateral central sulcus, in all cases. In 1 case, the cortical abnormality was irreversible, and the abnormal lesion, similar to that seen in laminar necrosis, persisted.
CONCLUSIONS: Bilateral frontal cortical abnormalities around the central sulcus and muscular weakness of all extremities might be the characteristic features of WEc.
METHODS: We retrospectively evaluated the clinical features and MRI findings in 3 cases of WEc in comparison with those of 7 previously reported cases.
RESULTS: Besides the classical triad of ocular abnormalities, ataxia and global confusion, muscular weakness of all extremities was frequently recognized (5 of 6 evaluable cases; 83%). During the clinical courses, 2 patients (20%) died and 1 fell into a vegetative state. The cortical abnormalities were distributed in the frontal and parietal lobes, especially around the bilateral central sulcus, in all cases. In 1 case, the cortical abnormality was irreversible, and the abnormal lesion, similar to that seen in laminar necrosis, persisted.
CONCLUSIONS: Bilateral frontal cortical abnormalities around the central sulcus and muscular weakness of all extremities might be the characteristic features of WEc.