Epidermolysis Bullosa Acquisita (Report of three Cases).

Three Libyan patients with epidermolysis bullosa acquisita (EBA) had adult onset of the disease with tense vesiculo-bullous lesions on the sites of pressure and trauma, healing with atrophic scars and milia formation. None of the patients had family history of epidermolysis bullosa. The 'diagnosis was based on clinical and histopathogical features snowing subepidermal bullae, and exclusion of other vesiculo-burous disease. In addition, the diagnosis in case I was confirmed by direct immunofluorescence studies showing linear deposits of IgS and C3 at the basement membrane zone. Case 2 was already having systemic lupus erythematosus for the last 3 years when she developed EBA. Case 3 was having anemia, leucopenia, raised ESR and gamma globulin. Thus, association of SLE was suspected in this case too although the diagnosis could not be confirmed.