Laboratory investigation; a journal of technical methods and pathology · 1993
High frequency of thymic ectopy in thyroids from autoimmune prone nonobese diabetic female mice.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Many M C, Drexhage H A, Denef J F
Аннотация
BACKGROUND: The female nonobese diabetic (NOD) mouse, a well known experimental model to study autoimmune type 1 diabetes, also spontaneously develops thyroiditis. In this study, we report an abnormally high frequency of thymic ectopy in thyroids from NOD mice.
EXPERIMENTAL DESIGN: Thyroids and thymuses from NOD mice and from control mice of different strains were processed for light and electron microscopy and for immunohistochemistry.
RESULTS: Ectopic thymic tissue was observed in the thyroids of 80% of female NOD mice, whereas it was not found in control age-paired female mice from various other strains. The thymic tissue was present beneath the capsule as a large and unique fragment consisting of both a cortical dark one and a medullary light region. Thymic ectopies, as the thymus itself, contained thymocytes expressing both L3T4 and Lyt2 antigens, specific respectively for T helper and T suppressor/cytotoxic cells. Cortical and medullary epithelial cells were also easily identified by electron microscopy and by immunohistochemical staining using ER-TR4 and ER-TR5 monoclonal antibodies.
CONCLUSIONS: Our observation could be an indication for a relation between abnormal thymus development and autoimmune disorder such as thyroiditis.
EXPERIMENTAL DESIGN: Thyroids and thymuses from NOD mice and from control mice of different strains were processed for light and electron microscopy and for immunohistochemistry.
RESULTS: Ectopic thymic tissue was observed in the thyroids of 80% of female NOD mice, whereas it was not found in control age-paired female mice from various other strains. The thymic tissue was present beneath the capsule as a large and unique fragment consisting of both a cortical dark one and a medullary light region. Thymic ectopies, as the thymus itself, contained thymocytes expressing both L3T4 and Lyt2 antigens, specific respectively for T helper and T suppressor/cytotoxic cells. Cortical and medullary epithelial cells were also easily identified by electron microscopy and by immunohistochemical staining using ER-TR4 and ER-TR5 monoclonal antibodies.
CONCLUSIONS: Our observation could be an indication for a relation between abnormal thymus development and autoimmune disorder such as thyroiditis.