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Recreational misuse of over-the-counter medications in Switzerland poses risks of severe toxicity, dependence, and dangerous drug interactions. Fourteen molecules have been identified as the most frequently diverted for their psychoactive effects: first-generation antihistamines, dextromethorphan, codeine, benzydamine, loperamide, butylscopolamine, and certain nasal decongestants. Prevention requires stricter regulation of distribution, increased awareness among healthcare professionals, and enhanced monitoring. Further research is essential to assess the magnitude of the phenomenon and to develop tailored strategies.