Progression from Candida (Candidozyma) auris colonization to bloodstream infection, New York State (NYS) and Chicago.

In 2 cohorts of patients colonized with Candida auris in New York State and Chicago, those who progressed to C auris bloodstream infection had comorbidities, including respiratory failure and mechanical ventilation, cocolonization with multidrug-resistant organisms, and extensive health care facility admissions, devices, and procedures. Fewer had traditional risk factors for candidemia (e.g. hematological malignancy, immunosuppression). Secondary prevention efforts are essential, including avoiding unnecessary device use and ensuring meticulous device maintenance and equipment cleaning and disinfection.