Journal of inorganic biochemistry · 2017
Synthesis and evaluation of the antibiotic and adjuvant antibiotic potential of organotin(IV) derivatives.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Barbosa Ana Soraya Lima, Guedes Jéssica de Siqueira, da Silva Douglas Rozendo, Meneghetti Simoni Margareti Plentz, Meneghetti Mario Roberto, da Silva Amanda Evelyn, de Araujo Morgana Vital, Alexandre-Moreira Magna Suzana, de Aquino Thiago Mendonça, de Siqueira Junior José Pinto, de Araújo Rodrigo Santos Aquino, da Cruz Ryldene Marques Duarte, Mendonça-Junior Francisco Jaime Bezerra
Аннотация
A series of organotin(IV) derivatives was investigated in vitro for their antibiotic and adjuvant antibiotic properties (efflux pump inhibitors) against Staphylococcus aureus strains that overexpress efflux pump proteins for norfloxacin (SA-1199B), erythromycin (RN-4220) and tetracycline (IS-58). Most organotin(IV) compounds showed significant antibacterial activity with small Minimum Inhibitory Concentration (MIC) values, some of which were close to 1.0μg/mL (3.1μM), but this feature was also associated with substantial cytotoxicity. Nevertheless, the cytotoxicity of these organotin(IV) compounds can be overcome when they are used as antibiotic adjuvants. Their remarkable adjuvant antibiotic properties allow potentiation of the action of tetracycline (against IS-58 strain) by up to 128-fold. This likely indicates that they can act as putative inhibitors of bacterial efflux pumps. These results reinforce organotin(IV) complexes as promising antibacterial agents, and many of these complexes, if associated with antibiotics, can act as potential adjuvant antibiotic candidates.