Orvosi hetilap · 2011
[Study of the Toll-like receptor 4 gene polymorphisms in diseases presenting with subclinical and chronic inflammation].
Аннотация на английскомСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Reismann Péter
Аннотация
UNLABELLED: Toll-like receptor 4, a central mediator of the innate immune response has been shown to play an important role not only in the defense mechanism against microorganism, but also other non-infectious inflammatory diseases such as atherosclerosis. The Asp299Gly and Thr399Ile, which are common co-segregation polymorphisms of the Toll-like receptor 4 gene have been shown to be associated with increased susceptibility for Gram-negative infections, but with a lower risk of carotid atherosclerosis and a reduced level of certain proinflammatory cytokines.
AIM: The role of these polymorphisms in diabetes mellitus with its late microvascular complications, in ischemic stroke, and in chronic periodontitis was investigated in three independent studies.
METHODS: In all studies the alleles of both polymorphisms were detected by polymerase chain reaction and subsequent cleavage by restriction endonucleases followed by gel electrophoresis.
RESULTS: In patients with type 2 diabetes, heterozygote carriers of the Asp299Gly and Thr399Ile polymorphisms of the Toll-like receptor 4 gene had a significantly reduced prevalence of peripheral neuropathy, while there was no association with any other diabetic microvascular complication, or with cerebral ischemia or with chronic periodontitis.
CONCLUSIONS: Toll-like receptor 4 gene polymorphisms are not enough sensitive genetic markers for risk stratification either in diabetes mellitus or in cerebral ischemia or in chronic periodontitis.
AIM: The role of these polymorphisms in diabetes mellitus with its late microvascular complications, in ischemic stroke, and in chronic periodontitis was investigated in three independent studies.
METHODS: In all studies the alleles of both polymorphisms were detected by polymerase chain reaction and subsequent cleavage by restriction endonucleases followed by gel electrophoresis.
RESULTS: In patients with type 2 diabetes, heterozygote carriers of the Asp299Gly and Thr399Ile polymorphisms of the Toll-like receptor 4 gene had a significantly reduced prevalence of peripheral neuropathy, while there was no association with any other diabetic microvascular complication, or with cerebral ischemia or with chronic periodontitis.
CONCLUSIONS: Toll-like receptor 4 gene polymorphisms are not enough sensitive genetic markers for risk stratification either in diabetes mellitus or in cerebral ischemia or in chronic periodontitis.