International journal of surgery (London, England) · 2025
Correlation analysis of postoperative cognitive function and event-related potentials in patients undergoing general anesthesia.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rao Xiuqin, Wei Conghui, Yi Pengcheng, Long Chubing, Huang Qiang, Wang Xifeng, Zhong Maoling, You Yueyang, Hua Fuzhou, Lin Yue
Аннотация
BACKGROUND: As the population ages, both the proportion of elderly surgical patients and the incidence of postoperative delirium (POD) are rising. Due to the challenges in identifying POD, misdiagnosis and missed diagnosis remain common, highlighting the need for objective cognitive assessment tools.
OBJECTIVE: This article aims to compare event-related potentials (ERPs) characteristics between patients with and without POD following general anesthesia, and to evaluate the potential of ERPs as predictive diagnostic markers for POD.
METHODS: POD was assessed in 28 patients with gastrointestinal tumors using the 3D-CAM scale on postoperative days 1, 3, and 7. Task-related electroencephalograms (EEGs) were recorded using a 64-channel system approximately 10 days after surgery. ERP components P300 and N200, along with task accuracy, were analyzed to evaluate electrophysiological changes associated with POD.
RESULTS: P300 and N200 latencies were significantly prolonged and amplitudes reduced in patients with delirium. Receiver Operating Characteristic (ROC) curve analysis revealed strong diagnostic efficacy of ERP latency parameters in identifying POD.
CONCLUSIONS: Patients with POD demonstrated significant alterations in ERPs, particularly prolonged P300 and N200 latencies and a trend toward reduced amplitudes. These findings suggest that P300 and N200 may serve as promising, non-invasive electrophysiological markers for the detection of delirium; however, further studies with larger sample sizes and longitudinal designs are needed to validate their diagnostic utility.
OBJECTIVE: This article aims to compare event-related potentials (ERPs) characteristics between patients with and without POD following general anesthesia, and to evaluate the potential of ERPs as predictive diagnostic markers for POD.
METHODS: POD was assessed in 28 patients with gastrointestinal tumors using the 3D-CAM scale on postoperative days 1, 3, and 7. Task-related electroencephalograms (EEGs) were recorded using a 64-channel system approximately 10 days after surgery. ERP components P300 and N200, along with task accuracy, were analyzed to evaluate electrophysiological changes associated with POD.
RESULTS: P300 and N200 latencies were significantly prolonged and amplitudes reduced in patients with delirium. Receiver Operating Characteristic (ROC) curve analysis revealed strong diagnostic efficacy of ERP latency parameters in identifying POD.
CONCLUSIONS: Patients with POD demonstrated significant alterations in ERPs, particularly prolonged P300 and N200 latencies and a trend toward reduced amplitudes. These findings suggest that P300 and N200 may serve as promising, non-invasive electrophysiological markers for the detection of delirium; however, further studies with larger sample sizes and longitudinal designs are needed to validate their diagnostic utility.