Journal of pharmacy & bioallied sciences · 2025
Evaluation of Inflammatory Markers and Clinical Outcomes in Patients with Acute Pancreatitis: A Prospective Cohort Study.
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Dhebar Mruga Malay, Reddy A Likhitha, Natarajan Kishore Kumar, Seelan Ap Aravinda Sathya, Manikandan R, Ganesan Aswin, Shingala Harsh Chandulal, Rameshbabu Sushmitha, Prashanth A
Аннотация
BACKGROUND: Acute pancreatitis (AP) is a sudden inflammatory process of the pancreas that can lead to varying degrees of severity, ranging from mild discomfort to life-threatening conditions. Identifying key inflammatory markers at an early stage is crucial to predicting clinical outcomes and improving management.
OBJECTIVE: This study aims to evaluate the association between inflammatory markers-C-reactive protein (CRP), serum amylase, and white blood cell (WBC) count-and clinical outcomes in patients with acute pancreatitis.
METHODS: A prospective cohort study involving 120 patients diagnosed with AP was conducted. Inflammatory markers were measured at admission, and their relationship with clinical outcomes, including hospital stay, severity of pancreatitis, and complications, was assessed.
RESULTS: Elevated CRP and WBC count were associated with severe pancreatitis and poor outcomes. Serum amylase showed no significant correlation with the severity of the disease. CRP was the strongest predictor of prolonged hospital stay and complications.
CONCLUSION: CRP is a reliable inflammatory marker for predicting severe clinical outcomes in AP, suggesting its use for routine monitoring in clinical practice.
OBJECTIVE: This study aims to evaluate the association between inflammatory markers-C-reactive protein (CRP), serum amylase, and white blood cell (WBC) count-and clinical outcomes in patients with acute pancreatitis.
METHODS: A prospective cohort study involving 120 patients diagnosed with AP was conducted. Inflammatory markers were measured at admission, and their relationship with clinical outcomes, including hospital stay, severity of pancreatitis, and complications, was assessed.
RESULTS: Elevated CRP and WBC count were associated with severe pancreatitis and poor outcomes. Serum amylase showed no significant correlation with the severity of the disease. CRP was the strongest predictor of prolonged hospital stay and complications.
CONCLUSION: CRP is a reliable inflammatory marker for predicting severe clinical outcomes in AP, suggesting its use for routine monitoring in clinical practice.