Progress in neuro-psychopharmacology & biological psychiatry · 2000
Evolution of plasma homovanillic acid (HVA) levels during treatment in schizo-affective disorder.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Galinowski A, Castelnau C, Spreux-Varoquaux O, Bourdel M C, Olie J P, Loo H, Poirier M F
Аннотация
1. Plasma Homovanillic Acid (p HVA) levels were measured by HPLC (high performance liquid chromatography) in 5 schizo-affective depressed patients receiving a standardized treatment. (lithium, chlorpromazine and clomipramine) during 4 weeks. 2. Four patients were pretreated, without a washout period. 3. No significant difference was observed between patients and normal controls at baseline. Under treatment, pHVA levels increased (p<0.02) with clinical improvement (MADRS and PANSS scores). 4. Although effects of medications prior to the study period were not controlled, these findings suggest that depressed schizo-affective patients may have normal pHVA levels that increase with clinical improvement, unlike schizophrenic patients whose increased pHVA concentrations decline with neuroleptic treatment.