The American journal of gastroenterology · 2025
Prospective Evaluation of Opioid Cessation in Patients With Suspected Opioid-Induced Esophageal Dysfunction.
Клиническое исследование III фазыСтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Ezquerra-Durán A, Alcalá-González L, Araujo I K, Alcedo J, Serra J, Barba-Orozco E
Аннотация
INTRODUCTION: The causal relationship between chronic opioid use and esophageal motor dysfunction in symptomatic patients has not been established.
METHODS: A prospective before-and-after multicenter study, including chronic active opioid patients referred for esophageal motility tests because of nonobstructive dysphagia.
RESULTS: Thirty-seven patients were evaluated, and 27 (73%) had criteria for opioid-induced esophageal dysfunction. In 19 patients who discontinued opioids for at least 7 days, esophageal motor disorders resolved in 10 (52.6%), accompanied by a clinical success response (defined as Eckardt ≤3) in 64.3%.
DISCUSSION: Discontinuation of opioids is associated with clinical and esophageal motility improvement in up to half of the patients.
METHODS: A prospective before-and-after multicenter study, including chronic active opioid patients referred for esophageal motility tests because of nonobstructive dysphagia.
RESULTS: Thirty-seven patients were evaluated, and 27 (73%) had criteria for opioid-induced esophageal dysfunction. In 19 patients who discontinued opioids for at least 7 days, esophageal motor disorders resolved in 10 (52.6%), accompanied by a clinical success response (defined as Eckardt ≤3) in 64.3%.
DISCUSSION: Discontinuation of opioids is associated with clinical and esophageal motility improvement in up to half of the patients.