The Journal of infectious diseases · 2017
Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011.
СтатьяПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
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Chakraborty Apurba, Rahman Mahmudur, Hossain M Jahangir, Khan Salah Uddin, Haider M Sabbir, Sultana Rebeca, Ali Rimi Nadia, Islam M Saiful, Haider Najmul, Islam Ausraful, Sultana Shanta Ireen, Sultana Tahmina, Al Mamun Abdullah, Homaira Nusrat, Goswami Doli, Nahar Kamrun, Alamgir A S M, Rahman Mustafizur, Mahbuba Jamil Khondokar, Azziz-Baumgartner Eduardo, Simpson Natosha, Shu Bo, Lindstrom Stephen, Gerloff Nancy, Davis C Todd, Katz Jaqueline M, Mikolon Andrea, Uyeki Timothy M, Luby Stephen P, Sturm-Ramirez Katharine
Аннотация
BACKGROUND: In March 2011, a multidisciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based active surveillance for influenza in Bangladesh, to assess transmission and contain further spread.
METHODS: We collected clinical and exposure history of the case patients and monitored persons coming within 1 m of a case patient during their infectious period. Nasopharyngeal wash specimens from case patients and contacts were tested with real-time reverse-transcription polymerase chain reaction, and virus culture and isolates were characterized. Serum samples were tested with microneutralization and hemagglutination inhibition assays. We tested poultry, wild bird, and environmental samples from case patient households and surrounding areas for influenza viruses.
RESULTS: Two previously healthy case patients, aged 13 and 31 months, had influenzalike illness and fully recovered. They had contact with poultry 7 and 10 days before illness onset, respectively. None of their 57 contacts were subsequently ill. Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isolated from the case patients and from chicken fecal samples collected at the live bird markets near the patients' dwellings.
CONCLUSION: Identification of H5N1 cases through population-based surveillance suggests possible additional undetected cases throughout Bangladesh and highlights the importance of surveillance for mild respiratory illness among populations frequently exposed to infected poultry.
METHODS: We collected clinical and exposure history of the case patients and monitored persons coming within 1 m of a case patient during their infectious period. Nasopharyngeal wash specimens from case patients and contacts were tested with real-time reverse-transcription polymerase chain reaction, and virus culture and isolates were characterized. Serum samples were tested with microneutralization and hemagglutination inhibition assays. We tested poultry, wild bird, and environmental samples from case patient households and surrounding areas for influenza viruses.
RESULTS: Two previously healthy case patients, aged 13 and 31 months, had influenzalike illness and fully recovered. They had contact with poultry 7 and 10 days before illness onset, respectively. None of their 57 contacts were subsequently ill. Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isolated from the case patients and from chicken fecal samples collected at the live bird markets near the patients' dwellings.
CONCLUSION: Identification of H5N1 cases through population-based surveillance suggests possible additional undetected cases throughout Bangladesh and highlights the importance of surveillance for mild respiratory illness among populations frequently exposed to infected poultry.