Neuron · 2020
Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Kwak Hankyul, Koh Wuhyun, Kim Sangwoo, Song Kiyeong, Shin Jeong-Im, Lee Jung Moo, Lee Elliot H, Bae Jin Young, Ha Go Eun, Oh Ju-Eun, Park Yongmin Mason, Kim Sunpil, Feng Jiesi, Lee Seung Eun, Choi Ji Won, Kim Ki Hun, Kim Yoo Sung, Woo Junsung, Lee Dongsu, Son Taehwang, Kwon Soon Woo, Park Ki Duk, Yoon Bo-Eun, Lee Jaeick, Li Yulong, Lee Hyunbeom, Bae Yong Chul, Lee C Justin, Cheong Eunji
Аннотация
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
Предметные рубрики MeSH
Aldehyde Dehydrogenase 1 FamilyAmine Oxidase (Copper-Containing)AnimalsAstrocytesBestrophinsFemaleGABA AntagonistsImmunohistochemistryInhibitory Postsynaptic PotentialsMacrolidesMaleMiceMice, KnockoutMicroscopy, ElectronNeural InhibitionNeuronsPatch-Clamp TechniquesPicrotoxinPrimary Cell CulturePyridazinesRNA, Small InterferingRetinal DehydrogenaseThalamusTouch Perceptiongamma-Aminobutyric Acid