Fitoterapia · 2025
Isolation and characterization of xuetonlignans L-P, previously undescribed spirobenzofuranoid dibenzocyclooctadiene lignans from the fruits of Kadsura heteroclita.
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Su Wei, Yuan Hanwen, Aamer Muhammad, Zhou Xudong, Zhou Kang, Li Ling, Yang Yupei, Xie Qingling, Liu Shiqi, Fu Gang, Mao Yu, Li Bin, Wang Wei
Аннотация
Five previously undescribed spirobenzofuranoid dibenzocyclooctadiene lignans, xuetonlignans L-P (1-5), and three known dibenzocyclooctadiene lignans (6-8) were isolated from the fruits of Kadsura heteroclita. Their structures were elucidated by analysis of HR-ESI-MS, NMR spectroscopy, CD spectra and single-crystal X-ray structure determination. The hepatoprotective activity against H2O2-induced toxicity in HepG2 cells and anti-inflammatory activity against NO (nitric oxide) were performed. Compounds 4 and 8 showed potent hepatoprotective activity against H2O2-induced toxicity in HepG2 cells compared to the positive control, bicyclol. Furthermore, compound 6 significantly inhibited the NO production in LPS-induced RAW264.7 cells at a concentration of 20 μM.