Association between global visual scanning and cognitive function in schizophrenia.

OBJECTIVE

Abnormalities of global visual scanning have been well-recognized in schizophrenia patients. However, its relevance to various cognitive domains is still understudied. In the present study, we identified the association between global visual scanning and cognitive function in schizophrenia.

METHODS

Eye movement was captured and analyzed in 28 individuals with schizophrenia and 21 healthy controls in free viewing test. The MATRICS consensus cognitive battery (MCCB) was applied to evaluate cognitive function.

RESULTS

Consistent with previous reports, schizophrenia patients exhibited several eye movement abnormalities during global visual scanning and showed cognition deficits in MCCB test as compared with healthy controls. Fixation duration was significantly related to cognitive dysfunction in schizophrenia. Moreover, there was a potential that eye movement measures during landscape scanning, rather than face scanning, were preferentially related to cognitive dysfunction.

CONCLUSION

This study indicated the association between free visual scanning and various cognitive functions in schizophrenia, shedding light on the possibility that some eye movement measures during visual exploration could be a biomarker for cognitive deficits in schizophrenia.