Epidermolysis bullosa acquisita associated with vesicular cystitis.

A 55-year-old woman with epidermolysis bullosa acquisita (EBA) who had associated vesicular cystitis is described. The clinical, histological and immunohistological features of the skin and mucous membranes were in accordance with previous reports of this disease. The patient also had symptoms of cystitis, and a cystoscopic examination showed areas of erosions and vesicles in the wall of the urinary bladder. Histological and immunopathological studies of the urinary bladder demonstrated sub-mucosal vesicles, and linear deposits of IgG and C3 along the mucosal-lamina propria junction. These bladder changes may be induced by the autoantibodies present in EBA.