European journal of cancer care · 2019
Preliminary results of a counselling programme for fertility preservation in female cancer patients: The experience of the GEMME DORMIENTI network.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ciccarone Mariavita, Hohaus Stefan, Pulsoni Alessandro, Cavaceppi Paola, Franzò Simona, Fabbri Raffaella, Cudillo Laura, Battistini Roberta, Di Rocco Alice, Annibali Ombretta, Cox Maria Christina, Provenzano Ida, Abruzzese Elisabetta, Renzi Daniela, Tesei Cristiano, Anticoli Borza Paola, Cuccaro Annarosa, Andriani Alessandro, D'Elia Gianna Maria, Facchiano Antonio, Marchetti Paolo, Cantonetti Maria
Аннотация
OBJECTIVE: To describe a population of patients referred for fertility preservation (FP), how to efficiently provide FP care, and how FP care changed over time.
METHODS: This longitudinal observational study enrolled 281 female cancer patients referred between 2013 and 2016 to the non-profit organisation Gemme Dormienti ONLUS (GD) for FP care. All patients underwent the same battery of instrumental and laboratory diagnostic tests. GnRHa therapy was started at least seven days before CTh treatment.
RESULTS: From 2013 to 2016, we observed a progressive increase in the number of patients referred for FP care. Out of 251 eligible patients, 135 patients were treated with GnRHa only, and 72 patients underwent GnRHa therapy and cryopreservation. The median time from GD referral to oocyte and ovarian tissue cryopreservation was 11 and 5 days respectively. Tissue cryopreservation requests increased during our study period (from four cases in 2013 to 17 cases in 2016). During follow-up, 17β-estradiol and FSH levels were significantly increased (p < .0001), and AMH levels were significantly decreased (p < .0001).
CONCLUSION: The rapid increase in the number of patients who requested FP care and in the complexity of FP procedures overtime reflects the need to improve quality of life for cancer patients.
METHODS: This longitudinal observational study enrolled 281 female cancer patients referred between 2013 and 2016 to the non-profit organisation Gemme Dormienti ONLUS (GD) for FP care. All patients underwent the same battery of instrumental and laboratory diagnostic tests. GnRHa therapy was started at least seven days before CTh treatment.
RESULTS: From 2013 to 2016, we observed a progressive increase in the number of patients referred for FP care. Out of 251 eligible patients, 135 patients were treated with GnRHa only, and 72 patients underwent GnRHa therapy and cryopreservation. The median time from GD referral to oocyte and ovarian tissue cryopreservation was 11 and 5 days respectively. Tissue cryopreservation requests increased during our study period (from four cases in 2013 to 17 cases in 2016). During follow-up, 17β-estradiol and FSH levels were significantly increased (p < .0001), and AMH levels were significantly decreased (p < .0001).
CONCLUSION: The rapid increase in the number of patients who requested FP care and in the complexity of FP procedures overtime reflects the need to improve quality of life for cancer patients.
Предметные рубрики MeSH
AdolescentAdultAnti-Mullerian HormoneAntineoplastic AgentsCounselingCryopreservationEstradiolFemaleFertility PreservationFollicle Stimulating HormoneGonadotropin-Releasing HormoneHumansInfertility, FemaleLongitudinal StudiesLuteinizing HormoneOocyte RetrievalOocytesOvarian FollicleOvarian ReserveOvaryOvulation InductionPatient PreferencePrimary Ovarian InsufficiencyProgesteroneReferral and ConsultationYoung Adult