Thromboplastic and fibrinolytic activity of hydatidiform molar tissue and vesicular fluid.

We found similar levels of thromboplastic activity in molar tissue, vesicular fluid and normal placental tissue from pregnancies matched for gestational age. The fibrinolytic activity of molar tissue and vesicular fluid was, however, increased and vaginal haemorrhage tended to be heavier when fibrinolytic activity was high (p = 0.06). Subsequent choriocarcinoma occurred more frequently in patients with molar tissue which had low fibrinolytic activity (p = 0.08).