Alcohol-Related Liver Disease: Novel Insights into Mechanism.

Alcohol-related liver injury is complex and remains poorly understood. Research to date has pinpointed the role of oxidative stress, hepatic inflammation, and derangements in lipid metabolism as drivers of disease pathogenesis. More recent research has identified alterations in the gut microbiome, epigenetics, G protein-coupled receptors, and microRNA's as possible drivers of disease pathogenesis and may serve as potential new treatment targets.