A simple and efficacious criterion based on serum LH levels to time hCG administration for human in vitro fertilization.

OBJECTIVE

To test the efficacy of a simple criterion--LH level--for administration of hCG in an IVF program.

DESIGN

Prospective, with retrospective analysis of other criteria for hCG administration.

SETTING

University hospital IVF program.

PATIENTS AND INTERVENTIONS: Eighty-four patients, in 110 cycles, were given 150-300 IU at 10-11 A.M. daily beginning on day 3 of the cycle. Serum LH measured daily 8:30-9:30 A.M., hCG administered on night of day LH level first exceeded J, defined as minimum value + (day 3 value-minimum) x 1/3.

OUTCOME MEASURES: Pregnancy (after IVF + ET); serum concentrations of estradiol and LH.

RESULTS

Total and ongoing pregnancy per cycle: 35% and 27% respectively. If hCG is administered one day early or late by the J criterion, the pregnancy rate is reduced.

CONCLUSIONS

Pregnancies occurred over wide follicle diameter (14-21 mm) and estradiol level (229-2,050 pg/mL) ranges. LH is recommended for timing hCG administration.