Extravasation injury to the hand by intravenous phenytoin. Report of three cases.

Extravasation of intravenous phenytoin can result in serious soft-tissue complications. Three patients are presented, one of whom lost a hand. Assessment of circulation and early decompression fasciotomies may be necessary in such cases. Caution is recommended in the intravenous administration of phenytoin. Infusions at rates of less than 50 mg/min and education of nursing staff about this potential complication will decrease its incidence.