The diagnostic value of Renalase level in serum for chronic kidney disease with different stages.

OBJECTIVES

The study aimed to explore the role of renalase in chronic kidney disease (CKD) and establish a diagnostic cutoff value for chronic kidney disease (CKD).

METHODS

Researchers analyzed serum renalase levels in 44 healthy adults and 250 CKD patients across stages I to V, along with other kidney function indicators like blood urea nitrogen (BUN), serum creatinine (CRE), uric acid (UA), Cystatin-C (Cys-C), β2-microglobulin (β2-mg), and estimated glomerular filtration rate (eGFR).

RESULTS

Serum renalase concentrations progressively increased from stage I to V CKD patients, significantly correlating with advancing renal dysfunction. Strong correlations were found between renalase and age, CRE, eGFR, UA, Cys-C, BUN, β2-mg, and CKD stage (all P < 0.001), but not with gender. Notably, the receiver operating characteristic (ROC) curve analysis highlighted stage II CKD, with an AUC of 0.980 for renalase, suggesting a diagnostic threshold of 6.595 μg/ml, offering 89.3 % sensitivity and 98.6 % specificity.

CONCLUSIONS

These results underscore serum renalase as a sensitive indicator for early-stage CKD diagnosis, complementing current biomarkers in detecting kidney impairment. Thus, renalase emerges as a promising novel biomarker need further investigation in more extensive cohorts for enhancing early CKD prediction capabilities.