Grifolin derivatives from the fruiting bodies of Albatrellus dispansus.

Ten previously undescribed grifolin derivatives (1, 2, and 4-11), including three pairs of enantiomers, and five known analogs (3 and 12-15), were isolated from the ethanol extract of Albatrellus dispansus. Their chemical structures were determined based on spectroscopic analysis, electronic circular dichroism calculations, and acid hydrolysis. In addition, all 15 isolated compounds were evaluated for cytotoxicity and antibacterial activities. Compound 15 showed mild antibacterial activity against MRSA with MIC values of 6.2 μM. Compound 13 showed moderate cytotoxicity against the human cancer MCF-7 cell line with IC50 values of 4.06 μM.