Journal francais d'ophtalmologie · 2022
Thinning of specific retinal layers as a novel biomarker for adverse outcomes in high-risk pregnancy.
Наблюдательное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Hanhart J, Weill Y, Wasser L M, Zadok D, Glick A, Farkash R, Grisaro-Granovsky S, Sela H Y, Avitan T
Аннотация
PURPOSE: To investigate a potential association between retinal layer thinning and pregnancy-related adverse outcomes.
METHODS: A prospective observational study included 32 pregnant women between the ages of 18 and 45. Seventeen had uneventful pregnancies, and 15 experienced an adverse obstetrical outcome. Macular swept-source ocular coherence tomography was performed, and selective layers of the retina were evaluated. Adverse obstetrical outcome was defined as any of the following: preterm delivery, preeclampsia, pregnancy-induced hypertension, elevated liver function tests, thrombocytopenia and need for magnesium.
RESULTS: The inner superior ganglion cell layer (GCL) was found to be thinner in the cohort with composite adverse obstetrical outcomes than in the cohort without complications (84.5±6.9 vs. 89.5±6.1μm respectively; P=0.04). Total inner superior (295.5±39.1 vs. 302.5±12.7μm; P=0.03) and inferior retinal thickness (289.0±13.9 vs. 301.0±17.1μm; P=0.03) as well as total macular volume (7.5±0.3 vs. 7.7±0.3 mm3; P=0.02) were also lower in women with adverse obstetrical outcomes.
CONCLUSION: Thinning of the macular ganglion cell layer was associated with adverse outcomes in pregnancy. Larger studies are necessary to assess the potential role of macular GCL analysis in pregnancy.
METHODS: A prospective observational study included 32 pregnant women between the ages of 18 and 45. Seventeen had uneventful pregnancies, and 15 experienced an adverse obstetrical outcome. Macular swept-source ocular coherence tomography was performed, and selective layers of the retina were evaluated. Adverse obstetrical outcome was defined as any of the following: preterm delivery, preeclampsia, pregnancy-induced hypertension, elevated liver function tests, thrombocytopenia and need for magnesium.
RESULTS: The inner superior ganglion cell layer (GCL) was found to be thinner in the cohort with composite adverse obstetrical outcomes than in the cohort without complications (84.5±6.9 vs. 89.5±6.1μm respectively; P=0.04). Total inner superior (295.5±39.1 vs. 302.5±12.7μm; P=0.03) and inferior retinal thickness (289.0±13.9 vs. 301.0±17.1μm; P=0.03) as well as total macular volume (7.5±0.3 vs. 7.7±0.3 mm3; P=0.02) were also lower in women with adverse obstetrical outcomes.
CONCLUSION: Thinning of the macular ganglion cell layer was associated with adverse outcomes in pregnancy. Larger studies are necessary to assess the potential role of macular GCL analysis in pregnancy.