Journal of conservative dentistry and endodontics · 2026
Fungicidal efficacy of caprylic acid using three different bovine milk types against Candida albicans: An in vitro study.
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Pawar Anuja, Keswani Kiran, Shetty Pradeep, Kambli Vinod, Dubey Priyanka, Kachari Megha
Аннотация
BACKGROUND: The success of endodontic therapy depends on thorough biomechanical preparation and the use of effective intracanal irrigants to achieve a microbe-free canal before obturation. Candida albicans is the most commonly isolated fungus from infected root canals and has a strong dentin affinity. Owing to its resistance to several intracanal medicaments, including calcium hydroxide, alternative antifungal agents are required. Bovine milk, which contains caprylic acid - a medium-chain fatty acid with known antimicrobial properties, may provide a natural and biocompatible adjunct for root canal disinfection.
AIM: To evaluate the fungicidal effect of bovine milk containing caprylic acid using three different milk sources against C. albicans.
OBJECTIVES: To compare the antifungal efficacy of caprylic acid in goat, cow, and buffalo milk using the disc-diffusion method.
MATERIALS AND METHODS: Different bovine milks were tested for antifungal activity against C. albicans by the standard disc-diffusion method. Zones of inhibition were measured in millimetres.
STATISTICAL ANALYSIS: Chi-square and paired t-tests were applied.
RESULTS: Goat milk produced the widest inhibition zone, followed by buffalo and cow milk, demonstrating significant differences (P < 0.001).
CONCLUSION: Caprylic acid, derived from bovine milk, can serve as a natural, biocompatible alternative to existing intracanal irrigants to control fungal infections during endodontic therapy.
AIM: To evaluate the fungicidal effect of bovine milk containing caprylic acid using three different milk sources against C. albicans.
OBJECTIVES: To compare the antifungal efficacy of caprylic acid in goat, cow, and buffalo milk using the disc-diffusion method.
MATERIALS AND METHODS: Different bovine milks were tested for antifungal activity against C. albicans by the standard disc-diffusion method. Zones of inhibition were measured in millimetres.
STATISTICAL ANALYSIS: Chi-square and paired t-tests were applied.
RESULTS: Goat milk produced the widest inhibition zone, followed by buffalo and cow milk, demonstrating significant differences (P < 0.001).
CONCLUSION: Caprylic acid, derived from bovine milk, can serve as a natural, biocompatible alternative to existing intracanal irrigants to control fungal infections during endodontic therapy.