Preventive medicine reports · 2026
Cognitive benefits of a lifestyle-induced prediabetes remission intervention in Canada.
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Gudas-Cantin Christopher, Dionne Valérie, Gayda Mathieu, Gagnon Daniel, Ouellet Marie, Bherer Louis, Gagnon Christine, Iglesies-Grau Josep
Аннотация
OBJECTIVE: To assess the potential for preventing or reversing the cognitive decline associated with prediabetes and coronary heart disease.
METHODS: In the DIABEPIC-1 feasibility study, participants with coronary heart disease and prediabetes (HbA1c of 5.7% to 6.4%) underwent a 6-month multidisciplinary enhanced cardiac rehabilitation intervention in Canada in 2023. Cognitive performance was assessed at baseline and six months with the Montreal Cognitive Assessment (MoCA), Rey Auditory Learning Verbal Test (RAVLT), Digit Symbol Substitution Test (DSST), Trail Making Test (TMT), Stroop test, and Verbal Fluency (VFT) test. To account for practice effects in the absence of a control group, standardized regression-based (SRB) formulas and reliable change indexes (RCI) were applied.
RESULTS: Thirty participants completed the protocol. Significant improvements were observed in global cognition (MoCA), memory (RAVLT total learning and delayed recall), processing speed (DSST), and executive function (TMT-B, Stroop inhibition and switching, semantic VFT). SRB and RCI analyses showed some participants exceeded expected practice effects in certain cognitive domains. Weight loss was associated with improved processing speed, and reductions in HbA1c were linked to gains in processing speed. Participants achieving prediabetes remission showed greater cognitive improvement.
CONCLUSIONS: These findings suggest potential cognitive benefits of prediabetes remission and support further investigation.
METHODS: In the DIABEPIC-1 feasibility study, participants with coronary heart disease and prediabetes (HbA1c of 5.7% to 6.4%) underwent a 6-month multidisciplinary enhanced cardiac rehabilitation intervention in Canada in 2023. Cognitive performance was assessed at baseline and six months with the Montreal Cognitive Assessment (MoCA), Rey Auditory Learning Verbal Test (RAVLT), Digit Symbol Substitution Test (DSST), Trail Making Test (TMT), Stroop test, and Verbal Fluency (VFT) test. To account for practice effects in the absence of a control group, standardized regression-based (SRB) formulas and reliable change indexes (RCI) were applied.
RESULTS: Thirty participants completed the protocol. Significant improvements were observed in global cognition (MoCA), memory (RAVLT total learning and delayed recall), processing speed (DSST), and executive function (TMT-B, Stroop inhibition and switching, semantic VFT). SRB and RCI analyses showed some participants exceeded expected practice effects in certain cognitive domains. Weight loss was associated with improved processing speed, and reductions in HbA1c were linked to gains in processing speed. Participants achieving prediabetes remission showed greater cognitive improvement.
CONCLUSIONS: These findings suggest potential cognitive benefits of prediabetes remission and support further investigation.