The Journal of infection · 2014
Increased endothelial and macrophage markers are associated with disease severity and mortality in scrub typhus.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Otterdal Kari, Janardhanan Jeshina, Astrup Elisabeth, Ueland Thor, Prakash John A J, Lekva Tove, Abraham O C, Thomas Kurien, Damås Jan Kristian, Mathews Prasad, Mathai Dilip, Aukrust Pål, Varghese George M
Аннотация
OBJECTIVES: Scrub typhus is endemic in the Asia-Pacific region. Mortality is high even with treatment, and further knowledge of the immune response during this infection is needed. This study was aimed at comparing plasma levels of monocyte/macrophage and endothelial related inflammatory markers in patients and controls in South India and to explore a possible correlation to disease severity and clinical outcome.
METHODS: Plasma levels of ALCAM, VCAM-1, sCD163, sCD14, YKL-40 and MIF were measured in scrub typhus patients (n = 129), healthy controls (n = 31) and in infectious disease controls (n = 31), both in the acute phase and after recovery, by enzyme immunoassays.
RESULTS: Patients had markedly elevated levels of all mediators in the acute phase, differing from both healthy and infectious disease controls. During follow-up levels of ALCAM, VCAM-1, sCD14 and YKL-40 remained elevated compared to levels in healthy controls. High plasma ALCAM, VCAM-1, sCD163, sCD14, and MIF, and in particular YKL-40 were all associated with disease severity and ALCAM, sCD163, MIF and especially YKL-40, were associated with mortality.
CONCLUSIONS: Our findings show that scrub typhus is characterized by elevated levels of monocyte/macrophage and endothelial related markers. These inflammatory markers, and in particular YKL-40, may contribute to disease severity and clinical outcome.
METHODS: Plasma levels of ALCAM, VCAM-1, sCD163, sCD14, YKL-40 and MIF were measured in scrub typhus patients (n = 129), healthy controls (n = 31) and in infectious disease controls (n = 31), both in the acute phase and after recovery, by enzyme immunoassays.
RESULTS: Patients had markedly elevated levels of all mediators in the acute phase, differing from both healthy and infectious disease controls. During follow-up levels of ALCAM, VCAM-1, sCD14 and YKL-40 remained elevated compared to levels in healthy controls. High plasma ALCAM, VCAM-1, sCD163, sCD14, and MIF, and in particular YKL-40 were all associated with disease severity and ALCAM, sCD163, MIF and especially YKL-40, were associated with mortality.
CONCLUSIONS: Our findings show that scrub typhus is characterized by elevated levels of monocyte/macrophage and endothelial related markers. These inflammatory markers, and in particular YKL-40, may contribute to disease severity and clinical outcome.
Предметные рубрики MeSH
AdipokinesAdolescentAdultAgedAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCell Adhesion Molecules, NeuronalChitinase-3-Like Protein 1Endothelial CellsFemaleFetal ProteinsHumansIndiaInflammationIntramolecular OxidoreductasesLectinsLipopolysaccharide ReceptorsMacrophage ActivationMacrophage Migration-Inhibitory FactorsMacrophagesMaleMiddle AgedMonocytesReceptors, Cell SurfaceScrub TyphusVascular Cell Adhesion Molecule-1Young AdultCD163 AntigenActivated-Leukocyte Cell Adhesion Molecule