A highly selective H/D exchange reaction of 1,4-dihydropyridines.

Herein, we report a simple, economical, and effective acid-mediated method for the in situ deuteration of Hantzsch esters and their 4-substituted derivatives, including some drugs that constitute important calcium channel blockers which are effective for hypertension treatment. Hydrogen isotope exchange occurred selectively at α-alkyl C-H bonds in the 2,6-substituents.