Zhonghua zhong liu za zhi [Chinese journal of oncology] · 2001
[Expression of extraneuronal monoamine transporter gene and DNA repair gene vis-à-vis with antitumor efficacy of SarCNU in human tumor xenografts].
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Chen Z, Panasci L C, Carter C A
Аннотация
OBJECTIVE: To clarify if there are any correlations between extraneuronal monoamine transmitters (EMT), DNA repair gene expressions and SarCNU antitumor efficacy.
METHODS: EMT, DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) and excision repair cross-complementing rodent repair deficiency gene (ERCC1-6) expressions in 9 human xenograft tumor models were determined by RT-PCR. The results were compared with the antitumor effects of SarCNU on these tumor xenografts.
RESULTS: Multiple regression analysis revealed significant correlations of SarCNU antitumor activity with different combinations of gene expression. The most significant correlation was observed with all of the 4 genes expressed.
CONCLUSION: The results suggest that expression of both EMT and DNA repair genes, specifically, MGMT, ERCC2 and ERCC4, are important determinants of SarCNU activity against human tumors. While DNA repair decreases SarCNU's activity by repairing damaged DNA, EMT appears to enhance its antitumor efficacy.
METHODS: EMT, DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) and excision repair cross-complementing rodent repair deficiency gene (ERCC1-6) expressions in 9 human xenograft tumor models were determined by RT-PCR. The results were compared with the antitumor effects of SarCNU on these tumor xenografts.
RESULTS: Multiple regression analysis revealed significant correlations of SarCNU antitumor activity with different combinations of gene expression. The most significant correlation was observed with all of the 4 genes expressed.
CONCLUSION: The results suggest that expression of both EMT and DNA repair genes, specifically, MGMT, ERCC2 and ERCC4, are important determinants of SarCNU activity against human tumors. While DNA repair decreases SarCNU's activity by repairing damaged DNA, EMT appears to enhance its antitumor efficacy.
Предметные рубрики MeSH
AnimalsAntineoplastic AgentsCarmustineCarrier ProteinsDNA HelicasesDNA RepairDNA-Binding ProteinsGene Expression Regulation, NeoplasticHT29 CellsHumansMiceMice, NudeNeoplasm TransplantationNeoplasms, ExperimentalO(6)-Methylguanine-DNA MethyltransferaseOrganic Cation Transport ProteinsProteinsRNA, NeoplasmReverse Transcriptase Polymerase Chain ReactionTranscription FactorsTumor Cells, CulturedXenograft Model Antitumor AssaysXeroderma Pigmentosum Group D ProteinOrganic Cation Transporter 3