Antigenic relationship between human IgE and canine IgE.

Absorption of canine reaginic serum with anti-human IgE resulted in a substantial reduction in PK titre to ragweed. Anti-human IgE was also effective in eliciting reversed cutaneous anaphylaxis in the dog. This is conclusive evidence of antigenic similarity of canine and human IgE. The immunoelectrophoretic identification of canine IgE is described.