Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials · 2005
[Research on the protein C-activating property and influencial factors of protein C activator isolated from the venom of Agkistrodon halys].
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Hou Liqiang, Zhao Luning, Zhao Zhongxi, Huang Shaoling, He Quanhua, Kong Tianahn, Guan Jinxia
Аннотация
OBJECTIVE: To investigate the protein C-activating property and experimental conditions that may affect the activities of protein C activator (PCA-SV).
METHODS: PCA-SV's functional characteristic, possible anticoagulant and amidase activities were measured by method of APTT and that of specific chromogenic substrate respectively in various experimental conditions.
RESULTS: PCA-SV can specifically act on protein C. The pH-optimum and temperature-optimum for the action of PCA-SV were 6.0 - 7.0 and 37 - 40 degrees C respectively. The anticoagulants (heparin, sodium citrate) had no effect on the activities.
CONCLUSION: PCA-SV is a new protein C-activating reagent that has high potency and specificity.
METHODS: PCA-SV's functional characteristic, possible anticoagulant and amidase activities were measured by method of APTT and that of specific chromogenic substrate respectively in various experimental conditions.
RESULTS: PCA-SV can specifically act on protein C. The pH-optimum and temperature-optimum for the action of PCA-SV were 6.0 - 7.0 and 37 - 40 degrees C respectively. The anticoagulants (heparin, sodium citrate) had no effect on the activities.
CONCLUSION: PCA-SV is a new protein C-activating reagent that has high potency and specificity.